Small Molecule Human PK and Dose Projection
Join us for a comprehensive, full-day workshop dedicated to the fundamentals and latest advancements in human pharmacokinetics (PK) and dose prediction for small molecules. This intensive event brings together leading industry experts to share scientific principles and practical strategies for translating in vitro and preclinical data to project human efficacious dose.
The sessions will first focus on fundamental PK parameter predictions, covering topics such as human clearance in vitro-to-in vivo extrapolation (IVIVE), allometric scaling approaches, human volume of distribution prediction, and oral absorption, alongside an in-depth discussion of transporter-mediated hepatobiliary and renal clearance. The workshop will also cover the integration of predicted human PK parameters and PKPD relationship to project human efficacious dose using modeling approaches, ranging from classic compartmental models to physiologically-based PK (PBPK) and systems pharmacology models. The afternoon sessions will pivot toward human PK and dose prediction for emerging new modalities, such as peptides and strategic design of First-in-Human (FIH) studies. Concluding with an interactive panel discussion featuring all speakers, this workshop offers DMPK scientists, pharmacologists, and translational researchers a valuable platform to gain actionable insights and discuss the challenges of modern small molecule and new modality drug discovery and development.
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