Advanced ADME/PK Biopharma LC-MS/MS Method Development Training
This one-day advanced ADME/PK biopharma LC–MS/MS method development training lab course builds on prior mass spectrometry fundamentals with a focus on workflow optimization and practical application on the Sciex platform. The program begins with a recap of prior training and defined learning objectives, followed by a strategic overview of ADME/PK method development, including translating project goals into LC–MS/MS workflows, balancing throughput and data quality, and selecting between triple quadrupole and HRMS platforms.
Participants then rotate through hands-on stations featuring QTRAP and ZenoTOF systems, covering method setup and submission strategies across multiple acquisition modes. The afternoon sessions focus on data interpretation, including quantitation using SCIEX-OS, qualitative versus quantitative workflows, and instrument readiness. The course concludes with an overview of advanced workflows—such as metabolite identification, high-throughput analysis, intact and ICE-IEF approaches, and biotherapeutics-related methods—followed by closing reflections and discussion of future curriculum topics.
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