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Enhancing Bioavailability and Manufacturability with Enabling Formulation Technologies for Oral Small Molecule Drug Product Development
December 2, 2025 @ 8:45 am - 5:30 pm
From Lead Optimization and Candidate Nomination Through Clinical Development
It is well known that a majority of small molecule late discovery and development pipelines are populated by compounds that are poorly soluble, and/or permeable. This has resulted in increasing use of established and emerging technologies to address these limitations. There are multiple ways that enabling technologies are impactful on the overall drug development effort, among them:
- Rendering poorly soluble molecules into tractable entities, with respect to: Solubility, Supersaturation on dissolution, Absorption and PK profile
- Enhancing the ability to efficiently modify and optimize the performance of drug products in response to pre-preclinical, preclinical and early clinical in vivo data
- Helping to ensure that the dosage form(s) used in clinical development are appropriate to the target, with respect to pharmacokinetic (PK) and pharmacodynamic (PD) profiles
The workshop will describe and discuss approaches, with case studies, that address the iterative, interdependent, multidisciplinary nature of effective drug product development, with focus on small molecules that require enabling technologies.
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