The Expanding Peptide Conjugate Landscape: Strategies for Complex Peptide Synthesis

The Expanding Peptide Conjugate Landscape: Strategies for Complex Peptide Synthesis

With peptide conjugate therapies achieving blockbuster sales and around 300 PDCs having entered clinical development, interest is expanding across new conjugate types and therapeutic applications.

RDCs, PDCs, POCs/PPMOs, and APCs pose distinct synthesis challenges shaped by peptide structure, linker and payload properties, and conjugation chemistry. Following a brief overview of these conjugate types, the speaker will discuss how route selection and downstream processing work together to meet purity, scale, and timeline requirements. Case studies will demonstrate how these approaches are applied in practice.

The session will also place peptide synthesis within BioDuro’s dedicated peptide platform, which connects peptide DEL, biology, chemistry, and early-stage CMC capabilities. Join us for a focused, case-based discussion of the chemistry behind complex peptide conjugate programs.

What you will learn

• Understand the commercial and clinical trends driving peptide conjugate growth
• Recognize key synthesis considerations across RDCs, PDCs, POCs/PPMOs, and APCs
• Evaluate how route selection, conjugation, purification, and analytical methods influence project execution
• Gain practical insights from case studies demonstrating complex peptide synthesis and purification outcome

Speaker – Yuyan Chen, Ph.D.Senior Director of Chemistry, BioDuro